The Role of Medicinal Mushrooms in Cancer Therapy

The Role of Medicinal Mushrooms in Cancer Therapy

Shiitake Mushroom

  • Additional trials confirm increased survival, reduced side effects from chemotherapy and improved quality of life in patients with colorectal, hepatocellular, breast cancer and metastatic prostate cancer. In a trial with 69 patients with metastatic prostate cancer the 50% survival length of treated and control patients was 48 and 35 months, respectively while the the five-year survival rate of treated patients was 43% against 29% in the control group.
  • Although usually delivered by injection, Lentinan is also orally bioavailable although the clinical dosage is likely to be significantly higher.

Maitake Mushroom

  • In a separate study a combination of MD-fraction and whole Maitake fruiting body powder was reported to produce similar improvements: 58.3% of liver cancer patients, 68.8% of breast cancer patients and 62.5% of lung cancer patients.
  • In vivo studies also showed synergy between D-fraction and chemotherapy (mitomycin C) as well as significant alleviation of side effects from chemotherapy, including loss of appetite, vomiting, nausea, hair loss and leukopenia.

Almond Agaricus Mushroom

  • Agaricus blazei polysaccharide extracts show strong in-vitro and in-vivo activity against a range of cancer cell lines, including: lung and ovarian cancer.
  • Clinical studies are limited although Mizuno reports positive clinical results in a number of mainly breast cancer patients at unspecified dosage while Ahn reports increased NK-cell activity and reduced chemotherapy related side effects from A. blazei polysaccharide extract.
  • A 2008 study confirms increases in NK cell activity with A. blazei polysaccharide extract a dose of 3g/day.
Back to blog