Additional trials confirm increased survival, reduced side effects from chemotherapy and improved quality of life in patients with colorectal, hepatocellular, breast cancer and metastatic prostate cancer. In a trial with 69 patients with metastatic prostate cancer the 50% survival length of treated and control patients was 48 and 35 months, respectively while the the five-year survival rate of treated patients was 43% against 29% in the control group.
Although usually delivered by injection, Lentinan is also orally bioavailable although the clinical dosage is likely to be significantly higher.
In a separate study a combination of MD-fraction and whole Maitake fruiting body powder was reported to produce similar improvements: 58.3% of liver cancer patients, 68.8% of breast cancer patients and 62.5% of lung cancer patients.
In vivo studies also showed synergy between D-fraction and chemotherapy (mitomycin C) as well as significant alleviation of side effects from chemotherapy, including loss of appetite, vomiting, nausea, hair loss and leukopenia.
Almond Agaricus Mushroom
Agaricus blazei polysaccharide extracts show strong in-vitro and in-vivo activity against a range of cancer cell lines, including: lung and ovarian cancer.
Clinical studies are limited although Mizuno reports positive clinical results in a number of mainly breast cancer patients at unspecified dosage while Ahn reports increased NK-cell activity and reduced chemotherapy related side effects from A. blazei polysaccharide extract.
A 2008 study confirms increases in NK cell activity with A. blazei polysaccharide extract a dose of 3g/day.