Cordycepin | Bioactive Compounds in Cordycep Militaris

Cordycepin | Bioactive Compounds in Cordycep Militaris

Cordycepin, 3′-deoxyadenosine (9-(3-deoxy-β-Dribofuranosyl) adenine), a nucleoside analogue, has molecular formula C10H13N5O3, molecular weight 251.24, melting point 228o C–231o C (Figure 2). Cordycepin is a main active compound of C. militaris.

It has been used as a valuable chemical marker for quality control of Cordyceps strains.

Cordycepin has been shown to exert potential therapeutic for the treatment of cancer and other diseases.

Cordycepin has many intracellular targets such as nucleic acid apoptosis and cell cycle.

The structure of cordycepin is similar to the adenosine, a cellular nucleoside. Therefore it can act as a nucleoside analogue. The main mechanism of cordycepin is to inhibit purine biosynthesis pathway.

Cordycepin also induces RNA or DNA chain termination and interacts with receptors for mTOR which has an important role in the regulation of protein synthesis.

Cordycepin is converted into 5’mono- , di- and tri-phosphates and can inhibit the activity of ribose-phosphate, pyrophosphokinase and 5- phosphoribosyl-1-pyrophosphate amidotransferase enzyme which play important role in biosynthesis of purines.

Cordycepic acid is also a principal bioactive compound of C. militaris.

The structure was identified first as 1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid.

Later, this compound was crystallized and identified as d-mannitol. It is used in the anti-aging nutritional supplement and also for pro-sexual.


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